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CHAPTER 52 Anticoagulant, antiplatelet, and thrombolytic drugs COAGULATION: PHYSIOLOGY AND PATHOPHYSIOLOGY Hemostasis Thrombosis OVERVIEW OF DRUGS FOR THROMBOEMBOLIC DISORDERS ANTICOAGULANTS Heparin and Its Derivatives: Drugs That Activate Antithrombin Heparin (Unfractionated) Low …Inherited Causes of Thrombosis. Inherited Causes of Thrombosis. Increased levels of natural procoagulants. Factor V Leiden mutation (APC resistance)Condition. Protein C. Protein S. Antithrombin. Acute thrombosis. Decrease. Decrease. Decrease. Liver disease. Decrease. Decrease. Decrease. DIC. Decrease. Decrease …Clinical Background [return to contents]. Thrombophilia is characterized by hypercoagulability and an increased propensity for thrombosis. Almost 2 million Americans succumb annually to a thromboembolic event, 1 with venous thrombosis the third most common cardiovascular disease after ischemic heart disease and stroke. …Learn about excessive clotting disorders that can cause deep vein thrombosis (DVT), pulmonary embolism (PE), and other complications. Explore the laboratory tests, causes, signs and symptoms, as well as treatments related to DVT and PE and the underlying conditions that cause them.Warfarin-induced skin necrosis (or, more generally, Anticoagulant-induced skin necrosis) is a condition in which skin and subcutaneous tissue necrosis (tissue death) occurs due to acquired protein C deficiency following treatment with anti-vitamin K anticoagulants (4-hydroxycoumarins, such as warfarin).. Warfarin necrosis is a rare but severe …Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner). It is commonly used to treat blood clots such as deep vein thrombosis and pulmonary embolism and to prevent stroke in people who have atrial fibrillation, valvular heart disease or artificial heart valves. Less commonly it is …Test Selection and Interpretation [return to contents]. Anticoagulants. Warfarin (Coumadin ®). Dose Selection. During the first weeks of warfarin therapy, dosage is usually adjusted to obtain a stable therapeutic response. 3 Suboptimal dosing during this period leads to excessive bleeding in some patients. 3 To reduce the bleeding risk, …