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Methotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform methotrexate mole .
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Limited data available from long-term methotrexate studies in adults indicate that the initial clinical improvement is maintained for at least two years with continued therapy . The optimal methotrexate duration of therapy is unknown . When methotrexate is discontinued, the methotrexate arthritis usually worsens within 3 to 6 weeks .

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