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Br J Psychiatry. 2017 Apr;210(4):299. doi: 10.1192/bjp.210.4.299. Clozapine in
treatment-resistant schizophrenia. Samara M(1), Leucht S(1). Author information:3 Mar 2017 … The history of medicine is effectively one of trial and error. For millennia, plants
and potions were tried out on people and their effects observed …There is still “fear” among some clinicians about prescribing clozapine for
patients with treatment-resistant schizophrenia. Jenny Bryan takes a look at the
drug's …2 Oct 2017 … New evidence bolsters the reputation of clozapine as the “gold-standard”
antipsychotic for patients with treatment-resistant schizophrenia.mazine in treatment-resistant schizophrenia.6 In this study (the first to
demonstrate the superiority of clozapine in treatment-resistant schizo- phrenia)
patients …The antipsychotic properties of clozapine, a newly synthesized dibenzodiazepine
, were described in 1971, and the first clinical trials were reported in 1973 and …Elkis H, Meltzer HY (eds): Therapy-Resistant Schizophrenia. Adv Biol Psychiatry.
Basel, Karger, 2010, vol 26, pp 114–128. Role of Clozapine in Treatment- …10 May 2016 … Treatment resistance to what is often deemed the last line of schizophrenia
treatment, clozapine, is a burgeoning problem in psychiatric …Up to a third of patients with schizophrenia develop treatment resistance.
Clozapine has been established as the most effective antipsychotic medication
for …2 Jan 2018 … Clozapine in treatment-resistant schizophrenia – Volume 210 Issue 4 – Myrto
Samara, Stefan Leucht.16 Nov 2015 … Treatment-resistant schizophrenia patients have better outcomes with clozapine
compared with other standard antipsychotics, but despite its …15 Jun 2018 … Up to 30% of patients with treatment-resistant schizophrenia treated with
clozapine have residual positive symptoms. Clozapine augmentation …Treatment-resistant schizophrenia is the object of intense interest because of
recent developments in its treatment and aetiology. The actual definition of …23 Mar 2017 … Clozapine is often used in combination with other antipsychotic medicines for
treatment-resistant schizophrenia, and this review investigated …13 Apr 2017 … Although clinical guidelines endorse clozapine therapy in TRS, there seems to
be resistance by clinicians to prescribe clozapine at a suitable …The atypical antipsychotic risperidone may constitute an alternative to clozapine,
the current treatment of choice for refractory schizophrenia. The objectives of …20 Mar 2017 … Background: In around a third of people with schizophrenia, the … Augmentation
of Clozapine for Treatment-Refractory Schizophrenia: The …28 Jun 2017 … Clozapine is the most effective antipsychotic for the 25% to 33% of people with
schizophrenia who are treatment resistant, but not all people …The aim of this research is to understand how Clozapine, a drug used to treat
schizophrenia, produces its therapeutic effects. Clozapine is normally only used
in …9 Jul 2018 … Although clozapine is the treatment of choice for treatment-refractory
schizophrenia, 30–40% of patients have an insufficient response, and …