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July 23, 2018 at 2:27 pm #4864
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Persistent dry cough (with an incidence of a few percent) has been associated with ACE-inhibitor use and in practice can be a cause of discontinuation of ACE-inhibitor therapy. Two prospective, parallel-group, double-blind, randomized, controlled trials were conducted to assess the effects of losartan on the incidence of cough in hypertensive patients who had experienced cough while receiving ACE-inhibitor therapy. Patients who had typical ACE-inhibitor cough when challenged with lisinopril, whose cough disappeared on placebo, were randomized to losartan 50 mg, lisinopril 20 mg, or either placebo (one study, n=97) or 25 mg hydrochlorothiazide (n=135). The double-blind treatment period lasted up to 8 weeks. The incidence of cough is shown in Table 1 below.
Losartan is not a beta blocker. Instead it is an ARB. By blocking the action of angiotensin, losartan relaxes muscle cells and dilates blood vessels, reducing blood pressure. Losartan, sold under the brand name Cozaar, is used to treat high blood pressure (hypertension). It’s also used to lower the risk of stroke in some patients with heart disease. Losartan is an angiotensin receptor blocker (ARB) that blocks a substance that causes blood vessels to tighten.
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Persistent dry cough (with an incidence of a few percent) has been associated with ACE-inhibitor use and in practice can be a cause of discontinuation of ACE-inhibitor therapy. Two prospective, parallel-group, double-blind, randomized, controlled trials were conducted to assess the effects of losartan on the incidence of cough in hypertensive patients who had experienced cough while receiving ACE-inhibitor therapy. Patients who had typical ACE-inhibitor cough when challenged with lisinopril, whose cough disappeared on placebo, were randomized to losartan 50 mg, lisinopril 20 mg, or either placebo (one study, n=97) or 25 mg hydrochlorothiazide (n=135). The double-blind treatment period lasted up to 8 weeks. The incidence of cough is shown in Table 1 below.
Losartan is not a beta blocker. Instead it is an ARB. By blocking the action of angiotensin, losartan relaxes muscle cells and dilates blood vessels, reducing blood pressure. Losartan, sold under the brand name Cozaar, is used to treat high blood pressure (hypertension). It’s also used to lower the risk of stroke in some patients with heart disease. Losartan is an angiotensin receptor blocker (ARB) that blocks a substance that causes blood vessels to tighten.
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