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We studied B12 levels in our metformin-treated participants at two time points during DPP.The question clinically is whether we should be treating all patients who are taking metformin with a vitamin B12 supplement, or whether we should be testing them.Vitamin B12 levels are measured, often along with folate (another B vitamin) as a separate blood test.I read about the B12 level and Metformin people having lower levels. So after checking with MD if I could take B12 started them.A vitamin B12 deficiency can lead to irreversible nerve damage and even impaired cognition or dementia. The human body doesn’t manufacture vitamin B12, so people need to get it fromRather, she said, “People who are taking metformin should ask their doctor about measuring their B12 level.”Q. My husband takes metformin and some other medications as well as supplements. His last blood work showed high levels of Vitamin B12 (more than 2000 pg/ml), which is disconcerting. Is this harmful…Serum B12 levels were quantified using the Quantaphase II folate/vitamin B12 radioassay kit from Bio-Rad Laboratories (Hercules, CA).Our data confirm the relationship between metformin and reduced serum B12 levels beyond the background prevalence of biochemical B12 deficiency.”There is a small but significant risk of developing Vitamin B12 deficiency when people take metformin.”At the 5-year mark, more of those in the metformin group than the placebo group had low B12 levels, affecting 4.3% of the metformin group but just 2.3% of the placebo group.Patients taking metformin had statistically significant lower vitamin B₁₂ levels than those not receiving metformin (P<.0001; 95% confidence interval [CI] = -220 to -84 pg/mL).Their vitamin B12 levels were then checked at 5 years and at 13 years. Are There Risks to Taking Metformin Long-Term? The people taking metformin were found to have a 10% lower mean vitamin B12 level and higher borderline-low vitamin B12 level at 5 years.Taking extra vitamin B–12 is often necessary when you are taking metformin.These intake levels do not apply to people who suffer from vitamin B–12 deficiency. They usually require higher doses of vitamin B–12 to treat their condition.Among those taking metformin, average vitamin B12 levels were lower and 4 percent were deficient compared to 2 percent in the placebo group.3.MESH Terms & Keywords. Vitamin B12 Levels, Cobalamin, B12, Colchicine, PPI, Proton Pump Inhibitors, Metformin, Glucophage, Chloramphenicol.Editorial. Open Access. Vitamin B12 Deficiency and Metformin Use. Wendimere Reilly and Jasminka Z Ilich*.It is also used to treat polycystic ovarian syndrome, a disease linked to high blood glucose levels [8]. Metformin is currently being studied as a treatment for heart attack recovery [9]…But vitamin B–12 does more than just support healthy energy levels.One study of diabetic patients experiencing side effects of depression from Metformin found those who took B–12 enjoyed a more positive outlook. [3].Vitamin B12, also called cobalamin, is a water-soluble vitamin that is involved in the metabolism of every cell of the human body: it is a cofactor in DNA synthesis…Common Questions and Answers about Metformin and vitamin b12 deficiency.To add, diabetes drug metformin is a known cause of vitamin B12 deficiency. Optimal B12 serum is above 800pg/mL or 600pmol/L. If your B12 levels are under this, then sublingual B12 is highly recommended.