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Ambrisentan had no significant effects on the AUC0–last of R-warfarin [104.7; 90
% …. OD, once daily; PK, pharmacokinetics; PD, pharmacodynamics; ABS, …25 May 2013 … The overall aim of this thesis was to develop a PKPD-based pharmacometric
model for warfarin that describes the dose-response relationship …Warfarin Data. • PKPD Studies in Healthy Subjects. – 1.5 mg/kg single oral dose.
– Total racemic warfarin plasma concentration. – Prothrombin complex activity …Warfarin PK was described using a one-compartment model. CYP2C9 … A theory
-based PKPD model describes warfarin concentrations and clinical response.20 Oct 2016 … A theory‐based PKPD model describes warfarin concentrations and clinical
response. Expected PK and PD genotype effects were confirmed.We utilized an existing PK/PD model to perform clinical trial simulations of
pharmacogenomic-guided versus standard of care warfarin therapy. The primary
 …Warfarin is an anticoagulant normally used in the prevention of thrombosis and
thromboembolism, the formation of blood clots in the blood vessels and their …27 Apr 2006 … Warfarin is one of the most widely used anticoagulant drugs worldwide. It is
highly effective at antagonising the vitamin K dependent clotting …Parameters. Average. 2.5%. 97.5%. RSE. CL-S L/h/70kg. 0.234. 0.197. 0.272. 11
%. V-S L/70kg. 25.40. 22.40. 28.41. 6%. CL-R L/h/70kg. 0.141. 0.120. 0.155.16 Nov 2011 … Due to the unpredictable pharmacokinetic (PK) and pharmacodynamic (PD)
responses to warfarin, initiation of therapy is the most clinically …